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BI 1015550
CAS No. 1423719-30-5
BI 1015550( —— )
Catalog No. M36402 CAS No. 1423719-30-5
Nerandomilast (BI 1015550) is an orally active PDE4B inhibitor with IC50 of 7.2 nM. BI 1015550 has potential applications in inflammation, allergic diseases, pulmonary fibrosis and chronic obstructive pulmonary disease (COPD) with a good safety profile.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 90 | Get Quote |
|
| 5MG | 121 | Get Quote |
|
| 10MG | 187 | Get Quote |
|
| 25MG | 365 | Get Quote |
|
| 50MG | 542 | Get Quote |
|
| 100MG | 759 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameBI 1015550
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NoteResearch use only, not for human use.
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Brief DescriptionNerandomilast (BI 1015550) is an orally active PDE4B inhibitor with IC50 of 7.2 nM. BI 1015550 has potential applications in inflammation, allergic diseases, pulmonary fibrosis and chronic obstructive pulmonary disease (COPD) with a good safety profile.
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DescriptionNerandomilast (BI 1015550) is an orally active inhibitor of PDE4B with an IC50 value of 7.2 nM. Nerandomilast has good safety and potential applications in inflammation, allergic diseases, pulmonary fibrosis, and chronic obstructive pulmonary disease (COPD).
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In Vitro——
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In VivoAnimal Model:Rats.Dosage:0, 0.3, 1.0 and 3.0 mg/kg.Administration:Oral gavage; single dose.Result:Had minimal toxic and side effects on the intestines and stomach of rats, demonstrating biosafety.Animal Model:Male Suncus Murinus and Wistar rats; mice.Dosage:0.01, 0.1, 0.3, 1.0, 2.5 or 12.5 mg/kg.Administration:Oral gavage; single dose or twice daily for 6 days.Result:Effectively improved inflammation in lung tissue and reduced the pro-inflammatory factor TNF-α release.
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Synonyms——
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PathwayAngiogenesis
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TargetPDE
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RecptorPDE
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Research Area——
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Indication——
Chemical Information
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CAS Number1423719-30-5
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Formula Weight448.97
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Molecular FormulaC20H25ClN6O2S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 10 mg/mL (22.27 mM; Ultrasonic (<60°C)
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SMILESN(C1=C2C(=NC(=N1)N3CCC(CC3)C=4N=CC(Cl)=CN4)CCS2=O)C5(CO)CCC5
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Pouzet P A, et al. Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma. United States. US9150586.
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